Protective effects of fullerenol on carbon tetrachloride. Concomitant treatment of rats with a nonhepatotoxic dose of dichloromethane 6 mmolkg, ip significantly potentiated the hepatotoxicity of carbon tetrachloride 2 mmolkg, ip. Carbon tetrachloride ccl 4 is a wellknown model compound for inducing chemical hepatic injury. Protective effects of pergularia daemia roots against. Dichloromethane potentiation of carbon tetrachloride.
The active constituent profile in cape gooseberry physalis peruviana l. In particular, for carbon tetrachloride poisoning, at a time when liver triglycerides are increasing rapidly, there is no increase in flux of fatty acids through the plasma compartment. Carbon tetrachlorideinduced hepatotoxicity in rats. Carbon tetrachlorideinduced hepatotoxicity in rat is. Evaluation of silymarin and or ginger effect on induced hepatotoxicity by carbon tetrachloride in male albino rats hassan h. Treatment of rats with carbon tetrachloride produced severe liver injury, as demonstrated by dramatic elevation of serum alt, ast. The most recent work in this field has inaugurated a third revolution in the study of.
Nonalcoholic fatty liver sensitizes rats to carbon. Histological effects of carotenoid on carbon tetrachloride. Hepatoprotective effects of phosphatidylserine liposomes on carbon tetrachloride. The protective effect of garlic oil, curcumin and their combination against ccl4 hepatotoxicity wa. Hepatoprotective activity of leptadenia reticulata stems against carbon tetrachlorideinduced hepatotoxicity in rats amit kumar nema 1, abhinav agarwal 2, varsha kashaw 1 1 pharmacognosy research laboratory, sagar institute of pharmaceutical sciences, sagar, madhya pradesh, india 2 pharmaceutics research laboratory, department of pharmaceutical sciences, dr. O, onikanni a, sabiu saheed abstract the present study was carried out to evaluate the hepatoprotective effects of aqueous extract of. In this study we have evaluated its potential protective effect on hepatic injury and fibrosis induced by carbon tetrachloride ccl 4. Alharbia, muzaffar iqbalb, sheikh fayaz ahmada a department of pharmacology and toxicology, college of pharmacy, king saud university, riyadh, saudi arabia b department of pharmaceutical chemistry, college of pharmacy, king saud. Rutin is a polyphenolic natural flavonoid which possesses antioxidant and anticancer activity. A total of seventy five rats were divided into five 5 groups of. M w fariss, k f bryson, e e hylton, h r lippman, c h stubin, and.
Carbon tetrachloride hepatotoxicity pharmacological. The present study was conducted to evaluate the hepatoprotective effects of an aqueous leaf extract of coccinia grandis on carbon tetrachloride ccl4 induced liver damage in albino rats. Toxicity was induced by using 30% ccl 4 suspended in olive oil 1. Wistar albino rats were administered 250 and 500 mgkg body weight extract orally for 10 consecutive days. Protective effects of coumarin and coumarin derivatives against carbon tetrachlorideinduced acute hepatotoxicity in rats. Posttranslational activation of endothelial nitric oxide.
Sgf on carbon tetrachloride ccl4induced hepatotoxicity in rats. Effect of cow urine distillate on liver function was studied in vivo in rats intoxicated with carbon tetrachloride ccl 4. Potential effects of garlic oil and curcumin on carbon. Don gentianaceae on carbon tetrachlorideinduced liver disorders were investigated.
Biochanin a protects against acute carbon tetrachlorideinduced hepatotoxicity in rats randa m. Rats were individually treated daily with 300 and 600 mgkg dose of either ethyl acetate, ethanol or aqueous extracts of a. Jayaraman, plant anatomy research centre, chennai, india. Carbon tetrachlorideinduced hepatotoxicity in rat is reversed by treatment with ribo. Carbon tetrachloride ccl 4 induced hepatotoxicity and nephrotoxicity model was used to investigate the possible mechanisms of fullerenol protection in spraguedawley rats in this study. Potentiation of carbon tetrachloride hepatotoxicity and lethality in type 2 diabetic rats. Pessayre d, cobert b, descatoire v, degott c, babany g, funckbrentano c, delaforge m, larrey d 1982 hepatotoxicity of trichloroethylenecarbon tetrachloride mixtures in rats. Modulatory effect of mangifera indica against carbon. Hepatoprotective effects of phosphatidylserine liposomes.
Protective effects of echinacoside on carbon tetrachloride. This work characterizes the metabolism disorders of hepatotoxicity induced by ccl 4 in a wistar rat model with a single dosage of 1 mlkg. Pdf hepatoprotective effect of cleome gynandra on carbon. Riboflavin attenuates carbon tetrachlorideinduced oxidative stress. Patel, moses samuel rajan, shenoy ashok, shabaraya a. Materials and methods plant material roots of pergularia daemia were collected from the maruthamalai hills, coimbatore, india in november 2006 and identified by p.
Quercetin and kaempferol were active components in the juice. A study to produce ideal hepatotoxicity rats models using varying concentrations of carbon tetrachloride ccl 4 was carried out. In this study, we evaluated the protective effect of bixin on liver damage induced by carbon tetrachloride ccl4 in. Glutathione plays an important role in the detoxification of most toxic agents. Examples of these natural products are garlic oil and curcumin that are characterized by their high antioxidant activity. Research article open access protective effect of bixin. Nonalcoholic fatty liver sensitizes rats to carbon tetrachloride hepatotoxicity shashikirandonthamsetty,1 vishakhas. The results of the present study showed the hepatoprotective effects of ps against ccl 4. The present study was designed to evaluate the possible hepatoprotective effects of riboflavin against carbon tetrachloride ccl 4 induced hepatic injury in rats. Protective effect of ricinus communisleaves extract on carbon tetrachloride induced hepatotoxicity in albino rats evan sabina princea, poorna parameswarib, rasool mahaboob khanc, aschool of biotechnology, chemical and biomedical engineering, vit university, vellore 632 014, india. Many herbal natural products have succeeded in reducing the toxicity of many toxins, such as that caused by carbon tetrachloride. We studied the role and regulation of nos in carbon tetrachloride ccl 4induced hepatotoxicity in newborn rats.
Pdf the aqueous seed extract of carica papaya linn. Groups df were administered orally the cholestin in diet for 1%, 2%, 3%, group g served as positive control and was given silymarin in diet for 12%. Hepatotoxicity was induced in rats by carbon tetrachloride ccl 4 treatment. Pdf carbon tetrachloride ccl4 induced hepatotoxicity. Effect of whey protein against fluvastatin and carbon. The present study evaluated the protective effects of the flavonoidrich fraction from rhizomes of smilax glabra roxb. Evaluation of silymarin and or ginger effect on induced. Despite being a cardinal experimental model, the induction of cirrhosis in rats by repeated exposure to carbon tetrachloride ccl4 has low reproducibility. Cleome gynandra has been used widely in indian indigenous system. Protection against carbon tetrachlorideinduced hepatotoxicity by pretreating rats with the hemisuccinate esters of tocopherol and cholesterol. View enhanced pdf access article on wiley online library html view download pdf for.
A sevenday long continuous collection of urine was performed in male rats in this experiment. Nacetyl cysteine, hepatotoxicity, carbon tetrachloride carbon tetrachloride is commonly used as a model to evaluate hepatotoxicity 1. In vivo protective effect of rosmarinus officinalis oil against carbon tetrachloride ccl4induced hepatotoxicity in rats. Hepatotoxicity was assessed by estimating the activities of marker enzymes and by histological studies. Toxicity was induced by using 30% ccl4 suspended in olive oil 1. Toxicity was determined by increases in serum sorbitol dehydrogenase and alanine aminotransferase activities measured 24 hr following the treatments. Protective effect of bixin on carbon tetrachlorideinduced. Introduction liver is the most important organ, which plays a pivotal role in regularity various physiological process. Pdf standardization of carbon tetrachlorideinduced. Carbon tetrachlorideinduced hepatotoxicity and nephrotoxicity in rats. Biochanin a protects against acute carbon tetrachloride. Hepatoprotective effect of adenema hyssopifolium g. Riboflavin reduces carbon tetrachlorideinduced increase in tnf riboflavin, a component of flavoproteins plays an important role in hepatoprotection. Attenuation of carbon tetrachlorideinduced hepatotoxicity.
Hepatoprotective and antioxidant activity of bombax ceiba. Phytochemical screening of this plant revealed the presence flavanoids, saponins, terpenoids and tannis. Murat bilgin h, atmaca m, deniz obay b, ozekinci s, tasdemir e, ketani a. Hepatotoxic interaction between carbon tetrachloride and. Hesperidin alleviates zinc oxide nanoparticle induced hepatotoxicity and oxidative stress. Protective effect of secoisolariciresinol diglycoside in.
The role of urtica dioica and nigella sativa in the. Leaves on carbon tetrachloride induced hepatotoxicity in rats jagir r. Protective effect of secoisolariciresinol diglycoside in carbon tetrachloride induced hepatotoxicity in rats sadiq s mareai 1, khalid m naji2, kavishankar gawli 3 and j rajesha 3 1department of chemistry, biochemistry division, university of thamar, thamar, yemen 2department of chemistry, university of sanaa, sanaa, yemen 3department of biochemistry, yuvarajas college, university of. Liver is a vital organ for the detoxification of toxic substances present in the body and hepatic injury is associated with excessive exposure to toxicants. Eer, on liver injury induced by carbon tetrachloride ccl 4 was investigated. In the present study, the hepatotoxicity induced by a single oral dose 2,000 mgkg of ccl 4 was compared between pregnant gestation days gd and 19 or postpartum postpartum days ppd 1, and 27 and nonpregnant rats. Effects of yam peel extract against carbon tetrachloride.
Protection of hepatic damage caused by carbon tetrachloride administration was observed by recording sgot, sgpt, alp and bln levels because they have been reported to be. Effect of whey protein against fluvastatin and carbon tetrachlorideinduced hepatotoxicity in rats ezz eldin s. The aim of this study was to investigate the possible protective effects of echinacoside, one of the phenylethanoids isolated from the stems of cistanches salsa, a chinese herbal medicine, on the free radical damage of liver caused by carbon tetrachloride in rats. In the present study the hepatoprotective effect of methonolic extract of c. The carotenoid bixin present in annatto is an antioxidant that can protect cells and tissues against the deleterious effects of free radicals. Protective effect of ricinus communis leaves extract on. Comparison of two protocols of carbon tetrachloride. This study was planned to investigate the protective effect of vitamin c on chronic and acute models of carbon tetrachloride ccl 4induced oxidative stress and changes of. Standardization of carbon tetrachlorideinduced hepatotoxicity in the rat. M zoology department, faculty of science, mansoura university, mansoura, egypt. Hepatoprotective activity of leptadenia reticulata stems. Carbon tetrachloride induces hepatotoxicity via oxidative stress and inflammation. Carbon tetrachloride ccl 4 is well known to induce hepatotoxicity after being metabolized to trichloromethyl free radical ccl 3 by cyp2e1.
Wistar albino rats weighing around 180200g were used. The present study was conducted to investigate the hepatoprotective activity of hydroethanolic fruit extract of rosa canina r. Carbon tetrachlorideinduced hepatotoxicity in pregnant. Hepatoprotective effect of rosa canina fruit extract. Ideal hepatotoxicity in rats using carbon tetrachloride ccl4. Modulatory potentials of the aqueous stem bark extract of mangifera indica on carbon tetrachlorideinduced hepatotoxicity in rats. Vitamin a deficiency potentiates carbon tetrachlorideinduced liver fibrosis in rats. Prevents carbon tetrachloride induced hepatotoxicity in rats article pdf available in international journal of applied research in natural products 22 june 2009 with 1,402 reads. The hepatoprotective and antioxidant effect of an ethanolic extract of rocket eruca sativa l. Protective effect of cow urine distillate in three dose levels and standard drug silymarin 100 mgkg, p. In the present study the hepatoprotective effect of rutin was evaluated against carbon tetrachloride ccl 4induced liver injuries in rats. The liver is an important organ for its ability to transform xenobiotics, making the liver tissue a prime target for toxic substances. Antioxidant potential of xylopia aethiopica adewale o.
Amaranthus lividus, antioxidant enzymes, carbon tetrachloride, hepatotoxicity. Carbon tetrachloride ccl 4induced hepatic damage in experimental sprague dawley rats. Mehendale1 this study tested whether hepatic steatosis sensitizes liver to toxicantinduced injury and. Modulatory effect of mangifera indica against carbon tetrachloride induced kidney damage in rats. An important biologicallyrelevant property of fullerenol is its ability to quench free radicals.
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